|
|
|
|
|
| TSUJITA,MIKI; SAKURABA,SHIGEKI; KURIBAYASHI,JUNYA; HOSOKAWA,YUKI; HATORI,EIKI; OKADA,YASUMASA; KASHIWAGI,MASANORI; TAKEDA,JUNZO; KUWANA,SHUN-ICHI. |
| Morphine is often used in cancer pain and postoperative analgesic management but induces respiratory depression. Therefore, there is an ongoing search for drug candidates that can antagonize morphine-induced respiratory depression but have no effect on morphine-induced analgesia. Acetylcholine is an excitatory neurotransmitter in central respiratory control and physostigmine antagonizes morphine-induced respiratory depression. However, physostigmine has not been applied in clinical practice because it has a short action time, among other characteristics. We therefore asked whether donepezil (a long-acting acetylcholinesterase inhibitor used in the treatment of Alzheimer's disease) can antagonize morphine-induced respiratory depression. Using the... |
| Tipo: Journal article |
Palavras-chave: Morphine; Donepezil; Rabbit; Respiratory depression; Alzheimer's disease; Cholinesterase inhibitor. |
| Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000400008 |
| |
|
|
| SAKURABA,SHIGEKI; TSUJITA,MIKI; ARISAKA,HIROFUMI; TAKEDA,JUNZO; YOSHIDA,KAZUICHI; KUWANA,SHUN-ICHI. |
| Buprenorphine is a mixed opioid receptor agonist-antagonist used in acute and chronic pain management. Although this agent's analgesic effect increases in a dose-dependent manner, buprenorphine-induced respiratory depression shows a marked ceiling effect at higher doses, which is considered to be an indicator of safety. Nevertheless, cases of overdose mortality or severe respiratory depression associated with buprenorphine use have been reported. Naloxone can reverse buprenorphine-induced respiratory depression, but is slow-acting and unstable, meaning that new drug candidates able to specifically antagonize buprenorphine-induced respiratory depression are needed in order to enable maximal analgesic effect without respiratory depression. Acetylcholine is... |
| Tipo: Journal article |
Palavras-chave: Buprenorphine; Donepezil; Rabbit; Respiratory depression; Cholinesterase inhibitor. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000400008 |
| |
|
|
|
